Klein S
Department of Genetics, Hebrew University of Jerusalem, Givat Ram, Israel.
Bioessays. 1994 Dec;16(12):869-71. doi: 10.1002/bies.950161203.
Premeiotic association of homologous chromosomes in the yeast, Saccharomyces cerevisiae has been shown, by means of fluorescent in situ hybridization (FISH). Time course and mutant studies show that the premeiotic associations are disrupted upon entry into meiosis, to be reestablished shortly before synapsis. The data are consistent with a model in which multiple, unstable interactions bring homologues together, prior to stable joining by recombination.
通过荧光原位杂交（FISH）技术已证实，在酿酒酵母中，同源染色体在减数分裂前会发生配对。时间进程和突变体研究表明，减数分裂前的配对在进入减数分裂时会被破坏，并在联会前不久重新建立。这些数据与一个模型相符，即在通过重组进行稳定连接之前，多个不稳定的相互作用会使同源染色体聚集在一起。
