Freedman R, Strömberg I, Nordström A L, Seiger A, Olson L, Bygdeman M, Wiesel F A, Granholm A C, Hoffer B J
Department of Psychiatry, Denver Veterans Administration Medical Center, CO.
Schizophr Res. 1994 Oct;13(3):259-70. doi: 10.1016/0920-9964(94)90051-5.
The distribution of schizophrenia in families supports the hypothesis of heritable risk factors in schizophrenia, but there is as yet no identification of an inherited neurobiological defect. Human embryonic brain tissue fragments, derived from first trimester abortions, can be transplanted into rat hosts, where they continue neuronal development and are accessible for neurobiological investigation. Hippocampal transplants derived from three schizophrenic women and a larger series of normal women have been studied. If there are heritable neuronal defects associated with schizophrenia, a proportion of the transplants from schizophrenic women would be expected to carry these defects. The transplants from the first two schizophrenic women showed profound abnormalities in survival and growth, compared to the series of transplants from normal women. The transplants from the third schizophrenic woman showed normal growth and development, as well as typical histological and electrophysiological features. The data must be regarded as preliminary, because of the small number of subjects that have been studied. However, they are consistent with the transmission of a defect in neuronal development to some of the offspring of schizophrenic women, a possibility consistent with other studies of the pathogenesis of schizophrenia. The mechanism of the defect in development remains to be identified.
精神分裂症在家族中的分布支持了精神分裂症存在遗传风险因素的假说，但目前尚未确定遗传性神经生物学缺陷。源自孕早期人工流产的人类胚胎脑组织碎片可移植到大鼠宿主体内，在那里它们会继续神经元发育，并且便于进行神经生物学研究。对来自三名精神分裂症女性和更多正常女性的海马移植体进行了研究。如果存在与精神分裂症相关的遗传性神经元缺陷，那么预计一部分来自精神分裂症女性的移植体将携带这些缺陷。与来自正常女性的一系列移植体相比，前两名精神分裂症女性的移植体在存活和生长方面表现出严重异常。第三名精神分裂症女性的移植体表现出正常的生长和发育，以及典型的组织学和电生理特征。由于所研究的对象数量较少，这些数据必须被视为初步的。然而，它们与精神分裂症女性的一些后代存在神经元发育缺陷的传递情况一致，这一可能性与其他关于精神分裂症发病机制的研究相符。发育缺陷的机制仍有待确定。
