Brenner B M
Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston.
Bull Mem Acad R Med Belg. 1994;149(1-2):121-5; discussion 125-7.
We hypothesize that retardation of renal development as occurs in individuals of low birth weight gives rise to increased postnatal risks for systemic and glomerular hypertension as well as enhanced risk of expression of renal disease. This hypothesis draws upon observations suggesting 1) a direct relationship between birth weight and nephron number, 2) an inverse relationship between birth weight and later-life hypertension, and 3) an inverse relationship between nephron number and blood pressure, irrespective of whether nephron number is reduced congenitally or in postnatal life (as from partial renal ablation or acquired renal disease). Additional clinical and epidemiological studies are needed to assess these initial impressions.
我们推测，低出生体重个体中出现的肾脏发育迟缓会增加出生后发生全身性高血压和肾小球高血压的风险，以及增加肾病表达的风险。这一推测基于以下观察结果：1）出生体重与肾单位数量之间存在直接关系；2）出生体重与晚年高血压之间存在反比关系；3）肾单位数量与血压之间存在反比关系，无论肾单位数量是先天性减少还是出生后减少（如部分肾切除或获得性肾病所致）。需要更多的临床和流行病学研究来评估这些初步印象。
