Omdal R, Jorde R, Mellgren S I, Husby G
Department of Rheumatology, University Hospital of Tromsø, Norway.
Lupus. 1994 Oct;3(5):413-7. doi: 10.1177/096120339400300509.
A controlled study with paired analysis of data was performed in 34 patients with systemic lupus erythematosus (SLE) and 34 age and sex-matched healthy controls. Autonomic function was not affected significantly in SLE patients as judged by standardised cardiovascular tests. Pancreatic polypeptide (PP) response to meal stimulation, which is impaired in parasympathetic failure, was for unknown reasons found to be significantly increased in SLE patients both in unstimulated and stimulated states. Neither cardiovascular nor serological tests could thus reveal significant autonomic dysfunction in SLE. Drugs with cardiovascular effects highly influenced autonomic function and could thus be misinterpreted as autonomic dysfunction caused by SLE itself.
对34例系统性红斑狼疮（SLE）患者和34例年龄及性别匹配的健康对照者进行了一项采用配对数据分析的对照研究。通过标准化心血管测试判断，SLE患者的自主神经功能未受到显著影响。胰腺多肽（PP）对进餐刺激的反应在副交感神经功能衰竭时受损，但不知何故，在SLE患者中，无论处于未刺激状态还是刺激状态，该反应均显著增加。因此，无论是心血管测试还是血清学测试，均未发现SLE存在明显的自主神经功能障碍。具有心血管效应的药物对自主神经功能有很大影响，因此可能被误解为由SLE本身引起的自主神经功能障碍。
