Oyanagi K, Makifuchi T, Ohtoh T, Ikuta F, Chen K M, Chase T N, Gajdusek D C
Center for Materials of Brain Diseases, Brain Research Institute, Niigata University, Japan.
Neurodegeneration. 1994 Dec;3(4):301-4.
The topographic distribution of brain atrophy in nine patients with parkinsonism-dementia complex of Guam (Guam PDC) was evaluated quantitatively, and compared with that in six Japanese patients with Alzheimer's disease or senile dementia of Alzheimer type (AD), five Japanese patients with progressive supranuclear palsy (PSP), and nine Japanese control subjects. Characteristic features of Guam PDC were as follows: (1) severe atrophy of the frontal and temporal cortex with relative preservation of the white matter; (2) atrophy of the tectum, tegmentum and cerebral peduncle of the midbrain, and (3) atrophy of the tegmentum and base of the upper pons. In contrast, sectional areas of the tectum and cerebral peduncle of the midbrain were relatively well preserved in PSP, while in AD there was no significant atrophy in the brain stem.
对9例关岛帕金森病痴呆综合征（关岛PDC）患者脑萎缩的地形分布进行了定量评估，并与6例日本阿尔茨海默病或阿尔茨海默型老年性痴呆（AD）患者、5例日本进行性核上性麻痹（PSP）患者以及9例日本对照受试者进行了比较。关岛PDC的特征如下：（1）额叶和颞叶皮质严重萎缩，白质相对保留；（2）中脑顶盖、被盖和大脑脚萎缩，以及（3）脑桥上段被盖和底部萎缩。相比之下，PSP患者中脑顶盖和大脑脚的横截面积相对保留良好，而AD患者脑干无明显萎缩。
