[实验性脑损伤后心房利钠肽、血管紧张素Ⅱ的变化及意义]
[Changes in and significance of atrial natriuretic peptide, angiotensin II after experimental brain injury].
作者信息
Zhang Z W, Yi S Y, Zhang X
机构信息
Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an.
出版信息
Zhonghua Yi Xue Za Zhi. 1994 Sep;74(9):545-7, 583.
We used the method of RIA determined the contents of atrial natriuretic peptide (ANP), angiotensin II (ANG II) in plasma and brain tissues after brain injury in 70 rats. The results showed that the ANP was significantly decreased in brain tissues on 6, 72 hours after brain injury. At the same time, the plasma and brain tissues ANG II, brain water contents were significantly increased. The results suggested that the unbalance of ANP and ANG II may be related to the pathophysiological process of brain edema.
我们采用放射免疫分析法（RIA）测定了70只大鼠脑损伤后血浆和脑组织中的心钠素（ANP）、血管紧张素II（ANG II）含量。结果显示，脑损伤后6小时、72小时脑组织中的ANP显著降低。同时，血浆和脑组织中的ANG II、脑含水量显著增加。结果提示，ANP与ANG II失衡可能与脑水肿的病理生理过程有关。
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