Ball R, Schwartz S L
Department of Pharmacology, Georgetown University, School of Medicine, Washington, DC 20007.
Comput Biol Med. 1994 Jul;24(4):269-76. doi: 10.1016/0010-4825(94)90023-x.
Physiologically based pharmacokinetic (PBPK) modeling is based on an understanding of the physical and biological factors governing drug distribution. It is a procedure requiring composition of differential equations describing the distribution of drugs among physiologically defined compartments. CMATRIX is a program that facilitates development of PBPK models. In CMATRIX, the model is represented as a matrix of transfer parameters; the program generates a corresponding system of differential equations, and solves them numerically. This system dramatically improves the ease with which PBPK models can be developed, allowing the freedom to construct subcompartments down to the receptor level.
基于生理学的药代动力学（PBPK）建模基于对控制药物分布的物理和生物学因素的理解。它是一个需要构建微分方程来描述药物在生理定义的隔室之间分布的过程。CMATRIX是一个有助于开发PBPK模型的程序。在CMATRIX中，模型表示为转移参数矩阵；该程序生成相应的微分方程组，并对其进行数值求解。该系统极大地提高了开发PBPK模型的便利性，允许自由构建直至受体水平的子隔室。
