Limberg M, Buggé C
Medical and Surgical Eye Care, San Luis Obispo, California 93401.
Cornea. 1994 Nov;13(6):496-9.
An open-label study of 20 normal, healthy volunteers was conducted to determine the tear concentrations after topical ocular application of ciprofloxacin 0.3% ophthalmic solution (Ciloxan). Tear samples were collected on Schirmer tear strips at 30 min, 2, 3, and 4 h, and were analyzed for ciprofloxacin using reverse-phase high-performance liquid chromatography. The results of this study showed the mean concentration, 4 h after dosing of ciprofloxacin, to be 16.0 micrograms/ml with 95% confidence limits of 8.15 and 23.79. It is concluded that concentrations of ciprofloxacin in tears were significantly greater than the minimum inhibitory concentrations for 90% of strains tested commonly reported for a majority of potential pathogens (i.e., < or = 2 micrograms/ml) 4 h after a single application of ciprofloxacin ophthalmic solution 0.3%.
对20名正常健康志愿者进行了一项开放标签研究，以确定局部眼部应用0.3%环丙沙星滴眼液（西普乐）后的泪液浓度。在30分钟、2小时、3小时和4小时时，用Schirmer泪液试纸收集泪液样本，并使用反相高效液相色谱法分析其中的环丙沙星。该研究结果显示，给药环丙沙星4小时后的平均浓度为16.0微克/毫升，95%置信区间为8.15至23.79。得出的结论是，单次应用0.3%环丙沙星滴眼液4小时后，泪液中环丙沙星的浓度显著高于大多数潜在病原体常见报道的90%受试菌株的最低抑菌浓度（即≤2微克/毫升）。
