Stanley A, Akbarsha M A
Department of Animal Science, Bharathidasan University, Tiruchirapalli, India.
Cytobios. 1994;79(316):51-8.
The effect of vincristine (VCR), an anticancer drug which brings about mitotic arrest by disturbing the microtubules of the spindle fibres, on the Leydig cells was investigated adopting ultrastructural and RIA of hormone techniques. The Leydig cells of VCR treated rats were necrotic and oedematous with severe damage caused to the steroidogenic machinery, viz the mitochondria and smooth endoplasmic reticulum. Such damage was duly reflected in the serum levels of hormones, wherein the androgen level was decreased with compensatory hypersecretion of follicle-stimulating hormone and luteinizing hormone. The results strongly implicate VCR in Leydig cell toxicity, and explain the problems in the reproductive performance faced by cancer patients receiving VCR as one of the drugs, both during treatment and after remission.
采用超微结构和激素放射免疫分析技术，研究了抗癌药物长春新碱（VCR）对睾丸间质细胞的影响。VCR处理的大鼠睾丸间质细胞出现坏死和水肿，类固醇生成机制（即线粒体和滑面内质网）受到严重损害。这种损害在激素的血清水平上得到了充分反映，其中雄激素水平下降，同时促卵泡激素和促黄体生成素出现代偿性分泌过多。结果有力地表明VCR对睾丸间质细胞具有毒性作用，并解释了癌症患者在接受VCR治疗期间和缓解后作为用药之一所面临的生殖性能问题。
