Miller J A, Lee S, Lao R, Karetzky M
Department of Pulmonary Medicine, Newark Beth Israel Medical Center, NJ.
Chest. 1995 Feb;107(2):440-6. doi: 10.1378/chest.107.2.440.
Gallium is presently used in the diagnosis of inflammatory, granulomatous, and neoplastic lung disease despite its many logistical problems. In contrast, thallium-201 scintigraphy, which was initially developed for myocardial imaging, offers the principal advantage of immediate imaging and diagnosis although it had not been investigated previously for use in pulmonary disease. In this study, thallium and gallium were prospectively compared with each other for the diagnosis of a variety of lung diseases. The overall concordance rate was 75%. Thallium was found to be significantly more sensitive than gallium for the entire group studied (N = 51, p < 0.006). In a subset of patients in whom a firm diagnosis was established, thallium was also found to be more sensitive, 86% vs 64%. The greater sensitivity of thallium-201 and its several inherent advantages suggest that thallium-201 should replace gallium-67 citrate as the radioisotope of choice for nuclear imaging of the chest.
尽管镓存在诸多后勤保障方面的问题，但目前仍用于炎症性、肉芽肿性和肿瘤性肺部疾病的诊断。相比之下，铊-201闪烁扫描最初是为心肌成像而开发的，尽管此前尚未对其在肺部疾病中的应用进行研究，但它具有即时成像和诊断的主要优势。在本研究中，对铊和镓在多种肺部疾病诊断中的应用进行了前瞻性比较。总体符合率为75%。在整个研究组（N = 51，p < 0.006）中，发现铊比镓的敏感性显著更高。在已确诊的部分患者亚组中，也发现铊更敏感，分别为86%和64%。铊-201更高的敏感性及其若干固有优势表明，铊-201应取代枸橼酸镓-67作为胸部核成像的首选放射性同位素。
