Capocasale E, Mazzoni M P, Tondo S, D'Errico G
Institute of General Surgery and Organ Transplantations, University of Parma, Italy.
Chemotherapy. 1994;40(6):435-40. doi: 10.1159/000239305.
Due to their uremic state and altered host response induced by immunodepressive therapy, renal transplant recipients are particularly susceptible to infectious complications with high morbidity and mortality. We here report the results of a prospective study with 170 renal transplant patients, undertaken to evaluate the efficacy of ceftriaxone in the prevention of wound and early urinary tract infection. No wound infection was observed, however, 12 patients (7.1%) developed urinary tract infections. On the basis of these data, we recommend ceftriaxone prophylaxis as a safe and effective measure to prevent transplant wound infection and to reduce the incidence of postoperative urinary tract infection.
由于肾移植受者的尿毒症状态以及免疫抑制治疗引起的宿主反应改变，他们特别容易发生感染并发症，发病率和死亡率都很高。我们在此报告一项对170例肾移植患者进行的前瞻性研究结果，该研究旨在评估头孢曲松预防伤口感染和早期尿路感染的疗效。未观察到伤口感染，然而，有12例患者（7.1%）发生了尿路感染。基于这些数据，我们推荐使用头孢曲松进行预防，作为预防移植伤口感染和降低术后尿路感染发生率的一种安全有效的措施。
