Chen R W, Wang Z W, Xu F X
General Hospital of Shenyang Army of People's Liberation Army.
Zhonghua Wai Ke Za Zhi. 1994 May;32(5):306-9.
The present paper has shown the effects of myocardial protection of isolated rat heart which were infused with different kinds of cardioplegia, and made to be arrested in the state of ischemia and absence of oxygen for 120 min. The heart rate, left ventricular constraction pressure and cardiac output volume, the myocardium water content and calcium content and pathological examination of myocardium were observed. The isolated rabbit heart under the circumstances of ischemia and absence of oxygen at 37 degrees C for 20 min Observations of the different kinds of cardioplegia. was observed that the different pH and oxygen content between artery and vein of the heart during the infusion of cardioplegia, the value of left ventricular constraction pressure multiplied by heart rates after reperfusion with autologous artery blood for 20 min. The values of CPK and MDA in right atrial blood, the ATP and CP volume of myocardium and pathologic study of myocardium were carried out. The results demonstrated that the warm blood cardioplegia had a better myocardial protection effect in supplying sufficient oxygen to myocardium during heart arrest, preserving and increasing energy store; controlling reperfusion in jury after ischemia, buffering acidosis and preserving heart status function. Therefore it has great value for improving the safety of the patients with complex and high risk heart diseases in perioperation.
本文展示了不同种类心脏停搏液灌注对离体大鼠心脏的心肌保护作用，使其在缺血缺氧状态下停搏120分钟。观察了心率、左心室收缩压、心输出量、心肌含水量、钙含量以及心肌病理检查。在37℃缺血缺氧环境下对离体兔心脏进行20分钟不同种类心脏停搏液的观察。观察了心脏停搏液灌注期间心脏动静脉不同的pH值和氧含量，用自体动脉血再灌注20分钟后左心室收缩压乘以心率的值。检测了右心房血中肌酸磷酸激酶（CPK）和丙二醛（MDA）的值、心肌中三磷酸腺苷（ATP）和磷酸肌酸（CP）含量以及心肌病理研究。结果表明，温血心脏停搏液在心脏停搏期间为心肌提供充足氧气、保存和增加能量储备、控制缺血后再灌注损伤、缓冲酸中毒以及维持心脏状态功能方面具有更好的心肌保护作用。因此，它对于提高复杂高危心脏病患者围手术期的安全性具有重要价值。
