Wei E T, Thomas H A
School of Public Health, University of California, Berkeley 94720-7360.
Eur J Pharmacol. 1994 Oct 3;263(3):319-21. doi: 10.1016/0014-2999(94)90729-3.
Thirty-three ovine corticotropin-releasing factor (CRF) analogs, systematically substituted with alanine (Ala) residues, were tested for inhibitory activity on edema induced in the pentobarbital-anesthetized rat paw by heat (immersion in 58 degrees C water for 1 min). The activity of each analog, administered 0.1 mg/kg i.v. 10 min before heat, was compared to the rank order of the analog's potency in stimulating adrenocorticotropin (ACTH) release from cultured rat pituicytes. A strong positive rank correlation was found between the anti-edema and neuroendocrine activities of these analogs.
对33种用丙氨酸（Ala）残基进行系统取代的绵羊促肾上腺皮质激素释放因子（CRF）类似物，测试了其对戊巴比妥麻醉大鼠爪因热（浸入58℃水中1分钟）诱导的水肿的抑制活性。每种类似物在热刺激前10分钟静脉注射0.1mg/kg，将其活性与该类似物刺激培养的大鼠垂体细胞释放促肾上腺皮质激素（ACTH）的效价排序进行比较。发现这些类似物的抗水肿和神经内分泌活性之间存在强烈的正等级相关性。
