Kentner M, Fischer T
Institute of Occupational and Social Medicine, University of Göttingen, Germany.
Int Arch Occup Environ Health. 1994;66(4):223-8. doi: 10.1007/BF00454359.
The threshold limit value (TLV) for lead (in Germany, the MAK value) is based on a certain blood lead concentration (in Germany BAT value = biological tolerance value for working materials) that is not to be exceeded; thereby a statistically significant association between air lead (PbA) and blood lead (PbB) is assumed. On the basis of a 10-year period of (1982-1991) biological and ambient monitoring of 134 battery factory staff and their workplaces, a PbA/PbB correlation with the regression equation PbB = 62.183 + 21.242 x Log 10 (PbA) (n = 1089, r = 0.274, P < 0.001) was calculated. These results are in line with those of several other investigations. The shape of the regression curve and the wide scattering of values led to the assumption that PbA values above the MAK value (0.1 mg/m3) do not necessarily result in increased PbB values. Similarly, PbA values lower than the MAK value do not guarantee PbB levels below the BAT value in every case. These observations are influenced by numerous confounders and intervening variables. It is concluded that lowering MAK values as a consequence of lowering BAT values is not mandatory.
铅的阈限值(在德国为MAK值)基于一定的血铅浓度(在德国,BAT值 = 工作物质的生物耐受值),该浓度不得超过;因此假设空气中铅(PbA)与血铅(PbB)之间存在统计学上的显著关联。基于对134名电池厂员工及其工作场所进行的为期10年(1982 - 1991年)的生物和环境监测,计算出PbA/PbB的相关性以及回归方程PbB = 62.183 + 21.242 x Log10(PbA)(n = 1089,r = 0.274,P < 0.001)。这些结果与其他几项调查的结果一致。回归曲线的形状和数值的广泛分散导致这样一种假设,即高于MAK值(0.1毫克/立方米)的PbA值不一定会导致PbB值升高。同样,低于MAK值的PbA值也不能保证在每种情况下PbB水平都低于BAT值。这些观察结果受到众多混杂因素和干预变量的影响。得出的结论是,由于降低BAT值而降低MAK值并非强制要求。