• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium.一种对盘基网柄菌中受体介导的腺苷酸环化酶激活所必需的丝裂原活化蛋白激酶。
J Cell Biol. 1995 Feb;128(3):405-13. doi: 10.1083/jcb.128.3.405.
2
The Dictyostelium MAP kinase kinase DdMEK1 regulates chemotaxis and is essential for chemoattractant-mediated activation of guanylyl cyclase.盘基网柄菌丝裂原活化蛋白激酶激酶DdMEK1调节趋化作用，对于趋化因子介导的鸟苷酸环化酶激活至关重要。
EMBO J. 1997 Jul 16;16(14):4317-32. doi: 10.1093/emboj/16.14.4317.
3
Activation of the mitogen-activated protein kinase ERK2 by the chemoattractant folic acid in Dictyostelium.趋化因子叶酸在盘基网柄菌中对丝裂原活化蛋白激酶ERK2的激活作用。
J Biol Chem. 1997 Sep 19;272(38):23690-5. doi: 10.1074/jbc.272.38.23690.
4
CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium.CRAC是一种含有普列克底物蛋白同源结构域的胞质蛋白，在盘基网柄菌中，它是受体和G蛋白介导的腺苷酸环化酶激活所必需的。
J Cell Biol. 1994 Sep;126(6):1537-45. doi: 10.1083/jcb.126.6.1537.
5
A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium.一种在盘基网柄菌趋化性和环磷酸腺苷信号转导中所需的新型Ras相互作用蛋白。
Mol Biol Cell. 1999 Sep;10(9):2829-45. doi: 10.1091/mbc.10.9.2829.
6
A novel cytosolic regulator, Pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium.一种新型胞质调节剂Pianissimo是盘基网柄菌中趋化因子受体和G蛋白介导的12跨膜结构域腺苷酸环化酶激活所必需的。
Genes Dev. 1997 Dec 1;11(23):3218-31. doi: 10.1101/gad.11.23.3218.
7
Amino acid substitutions in the Dictyostelium G alpha subunit G alpha 2 produce dominant negative phenotypes and inhibit the activation of adenylyl cyclase, guanylyl cyclase, and phospholipase C.盘基网柄菌Gα亚基Gα2中的氨基酸取代产生显性负性表型，并抑制腺苷酸环化酶、鸟苷酸环化酶和磷脂酶C的激活。
Mol Biol Cell. 1992 Jul;3(7):735-47. doi: 10.1091/mbc.3.7.735.
8
The Dictyostelium mitogen-activated protein kinase ERK2 is regulated by Ras and cAMP-dependent protein kinase (PKA) and mediates PKA function.盘基网柄菌促分裂原活化蛋白激酶ERK2受Ras和环磷酸腺苷依赖性蛋白激酶（PKA）调控，并介导PKA功能。
J Biol Chem. 1997 Feb 14;272(7):3883-6. doi: 10.1074/jbc.272.7.3883.
9
Multiple developmental roles for CRAC, a cytosolic regulator of adenylyl cyclase.CRAC（一种腺苷酸环化酶的胞质调节剂）的多种发育作用。
Dev Biol. 1999 Apr 1;208(1):1-13. doi: 10.1006/dbio.1998.9193.
10
Role of cAMP-dependent protein kinase in controlling aggregation and postaggregative development in Dictyostelium.环磷酸腺苷依赖性蛋白激酶在调控盘基网柄菌聚集及聚集后发育中的作用
Dev Biol. 1997 Mar 15;183(2):208-21. doi: 10.1006/dbio.1996.8499.

引用本文的文献

1
Regulatory differences between atypical and typical MAP kinases in Dictyostelium discoideum.盘基网柄菌中 atypical 和 typical MAP 激酶之间的调控差异。
Cell Signal. 2025 Jun;130:111701. doi: 10.1016/j.cellsig.2025.111701. Epub 2025 Feb 26.
2
An integrated, cross-regulation pathway model involving activating/adaptive and feed-forward/feed-back loops for directed oscillatory cAMP signal-relay/response during the development of .在……发育过程中，一个涉及激活/适应性以及前馈/反馈回路的整合交叉调节通路模型，用于定向振荡性环磷酸腺苷（cAMP）信号中继/响应 。 （注：原文句子不完整，“during the development of”后面缺少具体内容）
Front Cell Dev Biol. 2024 Jan 31;11:1263316. doi: 10.3389/fcell.2023.1263316. eCollection 2023.
3
Atypical MAP kinases - new insights and directions from amoeba.非典型 MAP 激酶——从变形虫中获得的新见解和新方向。
J Cell Sci. 2023 Oct 15;136(20). doi: 10.1242/jcs.261447. Epub 2023 Oct 16.
4
An atypical MAPK regulates translocation of a GATA transcription factor in response to chemoattractant stimulation.一种非典型的 MAPK 调节 GATA 转录因子的易位，以响应趋化刺激。
J Cell Sci. 2022 Aug 15;135(16). doi: 10.1242/jcs.260148. Epub 2022 Aug 19.
5
Carbon dioxide inhibits COVID-19-type proinflammatory responses through extracellular signal-regulated kinases 1 and 2, novel carbon dioxide sensors.二氧化碳通过细胞外信号调节激酶 1 和 2（新型二氧化碳传感器）抑制 COVID-19 型促炎反应。
Cell Mol Life Sci. 2021 Dec;78(24):8229-8242. doi: 10.1007/s00018-021-04005-3. Epub 2021 Nov 6.
6
Extracellular cAMP: The Past and Visiting the Future in cAMP-Enriched Extracellular Vesicles.细胞外 cAMP：富含 cAMP 的细胞外囊泡的过去与未来。
Adv Biol (Weinh). 2021 Dec;5(12):e2101064. doi: 10.1002/adbi.202101064. Epub 2021 Oct 28.
7
MAPK docking motif in the Dictyostelium Gα2 subunit is required for aggregation and transcription factor translocation.Dictyostelium Gα2 亚基中的 MAPK docking 基序对于聚集和转录因子易位是必需的。
Cell Signal. 2021 Nov;87:110117. doi: 10.1016/j.cellsig.2021.110117. Epub 2021 Aug 19.
8
Mitogen-activated protein kinase regulation of the phosphodiesterase RegA in early development.有丝分裂原激活的蛋白激酶对早期发育中磷酸二酯酶 RegA 的调节。
Microbiology (Reading). 2020 Feb;166(2):129-140. doi: 10.1099/mic.0.000868.
9
Proteomic and Transcriptomic Profiling Identifies Early Developmentally Regulated Proteins in .蛋白质组学和转录组学分析鉴定 中的早期发育调控蛋白。
Cells. 2019 Oct 1;8(10):1187. doi: 10.3390/cells8101187.
10
The Atypical MAP Kinase ErkB Transmits Distinct Chemotactic Signals through a Core Signaling Module.非典型 MAP 激酶 ErkB 通过核心信号模块传递独特的趋化信号。
Dev Cell. 2019 Feb 25;48(4):491-505.e9. doi: 10.1016/j.devcel.2018.12.001. Epub 2019 Jan 3.

本文引用的文献

1
Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro.细胞外信号调节蛋白激酶1和2在体外的调控及特性
J Biol Chem. 1993 Mar 5;268(7):5097-106.
2
Activation of MAP kinase by a dual specificity Tyr/Thr kinase.由双特异性酪氨酸/苏氨酸激酶激活丝裂原活化蛋白激酶。
Adv Second Messenger Phosphoprotein Res. 1993;28:219-25.
3
Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.丝裂原活化蛋白激酶p42mapk和p44mapk是成纤维细胞增殖所必需的。
Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8319-23. doi: 10.1073/pnas.90.18.8319.
4
Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus.血清诱导丝裂原活化蛋白激酶转位至细胞表面皱膜和细胞核。
J Cell Biol. 1993 Sep;122(5):1089-101. doi: 10.1083/jcb.122.5.1089.
5
Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts.生长因子可诱导成纤维细胞中丝裂原活化蛋白激酶（p42mapk和p44mapk）发生核转位，但不会诱导其激活剂丝裂原活化蛋白激酶激酶（p45mapkk）发生核转位。
J Cell Biol. 1993 Sep;122(5):1079-88. doi: 10.1083/jcb.122.5.1079.
6
A conserved kinase cascade for MAP kinase activation in yeast.酵母中用于丝裂原活化蛋白激酶激活的保守激酶级联反应。
Curr Opin Cell Biol. 1993 Apr;5(2):254-60. doi: 10.1016/0955-0674(93)90112-4.
7
The MAP kinase cascade is essential for diverse signal transduction pathways.丝裂原活化蛋白激酶级联反应对于多种信号转导途径至关重要。
Trends Biochem Sci. 1993 Apr;18(4):128-31. doi: 10.1016/0968-0004(93)90019-j.
8
A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf.由MEK激酶和Raf定义的MAP激酶调节网络中的差异。
Science. 1993 Apr 16;260(5106):315-9. doi: 10.1126/science.8385802.
9
The chemotactic factor N-formylmethionyl-leucyl-phenylalanine activates microtubule-associated protein 2 (MAP) kinase and a MAP kinase kinase in polymorphonuclear leucocytes.趋化因子N-甲酰甲硫氨酰-亮氨酰-苯丙氨酸可激活多形核白细胞中的微管相关蛋白2（MAP）激酶和一种MAP激酶激酶。
Biochem J. 1993 Mar 1;290 ( Pt 2)(Pt 2):483-8. doi: 10.1042/bj2900483.
10
cPLA2 is phosphorylated and activated by MAP kinase.胞浆型磷脂酶A2（cPLA2）被丝裂原活化蛋白激酶磷酸化并激活。
Cell. 1993 Jan 29;72(2):269-78. doi: 10.1016/0092-8674(93)90666-e.

一种对盘基网柄菌中受体介导的腺苷酸环化酶激活所必需的丝裂原活化蛋白激酶。

A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium.

作者信息

Segall J E, Kuspa A, Shaulsky G, Ecke M, Maeda M, Gaskins C, Firtel R A, Loomis W F

机构信息

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461.

出版信息

J Cell Biol. 1995 Feb;128(3):405-13. doi: 10.1083/jcb.128.3.405.

DOI:10.1083/jcb.128.3.405
PMID:7844154
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2120359/
Abstract

Analysis of a developmental mutant in Dictyostelium discoideum which is unable to initiate morphogenesis has shown that a protein kinase of the MAP kinase/ERK family affects relay of the cAMP chemotactic signal and cell differentiation. Strains in which the locus encoding ERK2 is disrupted respond to a pulse of cAMP by synthesizing cGMP normally but show little synthesis of cAMP. Since mutant cells lacking ERK2 contain normal levels of both the cytosolic regulator of adenylyl cyclase (CRAC) and manganese-activatable adenylyl cyclase, it appears that this kinase is important for receptor-mediated activation of adenylyl cyclase.

摘要

对盘基网柄菌中一个无法启动形态发生的发育突变体的分析表明，丝裂原活化蛋白激酶/细胞外信号调节激酶（MAP kinase/ERK）家族的一种蛋白激酶影响环磷酸腺苷（cAMP）趋化信号的传递和细胞分化。编码ERK2的基因座被破坏的菌株对cAMP脉冲的反应是正常合成环磷酸鸟苷（cGMP），但cAMP的合成很少。由于缺乏ERK2的突变细胞含有正常水平的腺苷酸环化酶胞质调节剂（CRAC）和锰激活的腺苷酸环化酶，因此这种激酶似乎对受体介导的腺苷酸环化酶激活很重要。