一种对盘基网柄菌中受体介导的腺苷酸环化酶激活所必需的丝裂原活化蛋白激酶。
A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium.
作者信息
Segall J E, Kuspa A, Shaulsky G, Ecke M, Maeda M, Gaskins C, Firtel R A, Loomis W F
机构信息
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461.
出版信息
J Cell Biol. 1995 Feb;128(3):405-13. doi: 10.1083/jcb.128.3.405.
Abstract
Analysis of a developmental mutant in Dictyostelium discoideum which is unable to initiate morphogenesis has shown that a protein kinase of the MAP kinase/ERK family affects relay of the cAMP chemotactic signal and cell differentiation. Strains in which the locus encoding ERK2 is disrupted respond to a pulse of cAMP by synthesizing cGMP normally but show little synthesis of cAMP. Since mutant cells lacking ERK2 contain normal levels of both the cytosolic regulator of adenylyl cyclase (CRAC) and manganese-activatable adenylyl cyclase, it appears that this kinase is important for receptor-mediated activation of adenylyl cyclase.
摘要
对盘基网柄菌中一个无法启动形态发生的发育突变体的分析表明，丝裂原活化蛋白激酶/细胞外信号调节激酶（MAP kinase/ERK）家族的一种蛋白激酶影响环磷酸腺苷（cAMP）趋化信号的传递和细胞分化。编码ERK2的基因座被破坏的菌株对cAMP脉冲的反应是正常合成环磷酸鸟苷（cGMP），但cAMP的合成很少。由于缺乏ERK2的突变细胞含有正常水平的腺苷酸环化酶胞质调节剂（CRAC）和锰激活的腺苷酸环化酶，因此这种激酶似乎对受体介导的腺苷酸环化酶激活很重要。
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Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro.细胞外信号调节蛋白激酶1和2在体外的调控及特性
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Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.丝裂原活化蛋白激酶p42mapk和p44mapk是成纤维细胞增殖所必需的。
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