体外受精（IVF）患者卵泡液中透明带抗体相关性评估。

Assessment of the relevance of zona pellucida antibodies in follicular fluid of in-vitro fertilization (IVF) patients.

作者信息

Papale M L, Grillo A, Leonardi E, Giuffrida G, Palumbo M, Palumbo G

机构信息

Department of Obstetric and Gynaecological Endocrinology, Catania University, Ospedale di Maternità S. Bambino, Italy.

出版信息

Hum Reprod. 1994 Oct;9(10):1827-31. doi: 10.1093/oxfordjournals.humrep.a138342.

DOI:10.1093/oxfordjournals.humrep.a138342

PMID:7844210

Abstract

The presence of anti-zona pellucida antibodies in the follicular fluid of 11 women who underwent in-vitro fertilization (IVF) and embryo transfer was analysed. Only infertile couples with tubal or unexplained pathologies were included in our study, which was aimed at investigating the relationship between anti-zona pellucida antibodies in follicular fluid and failed fertilization. Whether or not these antibodies were present in some or all follicles in the same patient was also investigated. Out of 55 follicular fluids analysed, 36.3% were positive to the test and no fertilization was observed in oocytes from these follicles, while 63.6% were negative, and the oocyte fertilization rate associated with these was 51.4%. The presence of anti-zona pellucida antibodies was positively correlated with the degree of fertilization failure (P < 0.001 chi 2 test).

摘要

分析了11名接受体外受精（IVF）和胚胎移植的女性卵泡液中抗透明带抗体的存在情况。本研究仅纳入了患有输卵管疾病或不明原因病理的不育夫妇，旨在研究卵泡液中抗透明带抗体与受精失败之间的关系。同时还研究了同一患者的部分或全部卵泡中是否存在这些抗体。在分析的55份卵泡液中，36.3%检测呈阳性，来自这些卵泡的卵母细胞未观察到受精，而63.6%为阴性，与之相关的卵母细胞受精率为51.4%。抗透明带抗体的存在与受精失败程度呈正相关（卡方检验，P < 0.001）。