用重组gp160免疫黑猩猩可诱导包膜特异性Th1记忆细胞，而感染1型人类免疫缺陷病毒则不能。

Immunization of chimpanzees with recombinant gp160, but not infection with human immunodeficiency virus type 1, induces envelope-specific Th1 memory cells.

作者信息

Mannhalter J W, Fischer M B, Wolf H M, Küpcü Z, Barrett N, Dorner F, Eder G, Eibl M M

机构信息

Immuno AG, Vienna, Austria.

出版信息

J Infect Dis. 1995 Feb;171(2):437-40. doi: 10.1093/infdis/171.2.437.

DOI:10.1093/infdis/171.2.437

Abstract

The human immunodeficiency virus (HIV) type 1 envelope protein (recombinant [r] gp160)-induced T cell lymphokine release pattern of chimpanzees immunized with HIVIIIB rpg160 tested and compared with rpg160-induced lymphokine releases of T cells from unimmunized, HIV-1-infected chimpanzees. The results showed that infection of chimpanzees with HIV-1 did not induce rgp160-specific memory T cells (as evidenced by the lack of Th1 and 2 type lymphokine releases after rgp160 stimulation). In contrast, T cells of rgp160-immunized chimpanzees released Th1 type lymphokines upon stimulation with rgp160 of HIVIIIB, HIVMN, and HIVRF. release was comparable whether chimpanzees were immunized with rgp160 only or also challenged with HIV-1 and protected or not protected. Thus, rgp160 immunization leads to generation of Th1 type memory cells. Whether Th1 type responses contribute to protection against HIV-1 infection has yet to be clarified.

摘要

用HIVIIIB重组[r] gp160免疫黑猩猩后，检测其1型人类免疫缺陷病毒（HIV）包膜蛋白诱导的T细胞淋巴因子释放模式，并与未免疫、感染HIV-1的黑猩猩的T细胞经rgp160诱导的淋巴因子释放情况进行比较。结果显示，黑猩猩感染HIV-1并未诱导产生rgp160特异性记忆T细胞（rgp160刺激后缺乏Th1和Th2型淋巴因子释放可证明）。相反，用rgp160免疫的黑猩猩的T细胞在受到HIVIIIB、HIVMN和HIVRF的rgp160刺激后会释放Th1型淋巴因子。无论黑猩猩是仅用rgp160免疫，还是同时受到HIV-1攻击且得到保护或未得到保护，淋巴因子释放情况都相当。因此，rgp160免疫可导致Th1型记忆细胞的产生。Th1型反应是否有助于预防HIV-1感染尚待阐明。