Heikkinen T, Ruuskanen O, Ziegler T, Waris M, Puhakka H
Department of Pediatrics, University of Turku, Finland.
J Pediatr. 1995 Feb;126(2):313-6. doi: 10.1016/s0022-3476(95)70569-4.
We performed a randomized, double-blind, placebo-controlled study to determine whether acute otitis media could be prevented by antibiotic therapy initiated promptly after the appearance of symptoms of upper respiratory tract infection. One hundred four children aged 1 to 4 years received a 7-day course of either amoxicillin-clavulanate or placebo. Acute otitis media developed in 9 (18%) of the 50 children receiving amoxicillin clavulanate and in 12 (22%) of the 54 children receiving placebo (p = 0.59).
我们进行了一项随机、双盲、安慰剂对照研究，以确定上呼吸道感染症状出现后立即开始使用抗生素治疗是否可预防急性中耳炎。104名1至4岁的儿童接受了为期7天的阿莫西林-克拉维酸或安慰剂治疗。接受阿莫西林-克拉维酸治疗的50名儿童中有9名（18%）发生了急性中耳炎，接受安慰剂治疗的54名儿童中有12名（22%）发生了急性中耳炎（p = 0.59）。
