Fahal A H, el Toum E A, el Hassan A M, Mahgoub E S, Gumaa S A
Department of Surgery, Faculty of Medicine, University of Khartoum, Sudan.
J Med Vet Mycol. 1994;32(5):343-8.
This is the first report on the fine structure of Actinomadura pelletieri. The in vitro ultrastructure of the organism and that of the grain in vivo were similar. The grain consisted of packed filaments with a faintly electron-dense matrix in between. The individual filament was septate, the cytoplasm was either vacuolated or contained intracellular organelles and the cytoplasmic membrane was adherent to the filamentous wall, which has three electron-dense and two electron-lucent layers. The absence of cement substance around the grain may partially explain the aggressive and destructive behaviour of this organism and may probably also explain its good response to medical treatment. The inflammatory host reaction was similar to that seen with all mycetoma organisms except that there was a massive neutrophil reaction. This was confirmed by electron microscopy.
这是关于佩氏马杜拉放线菌精细结构的首篇报道。该生物体的体外超微结构与体内颗粒的超微结构相似。颗粒由紧密排列的细丝组成，其间有轻度电子致密的基质。单根细丝有隔膜，细胞质要么呈空泡状，要么含有细胞内细胞器，细胞质膜附着于丝状壁，丝状壁有三层电子致密层和两层电子透亮层。颗粒周围缺乏黏合物质可能部分解释了该生物体的侵袭性和破坏性，也可能解释了其对药物治疗的良好反应。炎症宿主反应与所有足菌肿病原体引起的反应相似，只是有大量中性粒细胞反应。这一点通过电子显微镜得到了证实。
