Ohhata I, Ochi T, Kurebayashi S, Masutani H, Kikui M
Fourth Department of Internal Medicine, Osaka Prefectural Habikino Hospital, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1994 Oct;32(10):996-1000.
A 57-year-old woman came to our hospital complaining of multiple subcutaneous nodules that developed while she received corticosteroid therapy for pulmonary sarcoidosis. She was treated with interferon-alpha (IFN-alpha) at another hospital for C-type chronic hepatitis and she noticed these nodules with tenderness two months after treatment began. A biopsy specimen of the nodule revealed subcutaneous sarcoid granuloma. Her abnormally high serum-ACE value and subcutaneous nodules resolved after the dose of IFN-alpha was gradually reduced. IFN therapy should be used with care in cases of sarcoidosis in which IFN-gamma and T-lymphocytes are mainly involved.
一名57岁女性因在接受糖皮质激素治疗肺结节病期间出现多个皮下结节前来我院就诊。她曾在另一家医院接受干扰素-α（IFN-α）治疗丙型慢性肝炎，治疗开始两个月后她注意到这些有压痛的结节。结节的活检标本显示为皮下结节病肉芽肿。在逐渐减少IFN-α剂量后，她异常升高的血清血管紧张素转换酶（ACE）值和皮下结节消失。对于主要涉及IFN-γ和T淋巴细胞的结节病病例，应谨慎使用IFN治疗。
