Coster D J, Williams K A
Department of Ophthalmology, Flinders University of South Australia, Adelaide.
Klin Monbl Augenheilkd. 1994 Nov;205(5):271-4. doi: 10.1055/s-2008-1045527.
The value of a register of corneal grafts is that it can provide new data about the long-term outcome of corneal transplantation and may allow a more reasoned distribution of scarce donor corneas. The large numbers of cases and events can accommodate wide variations in practice patterns without losing statistical power. The Australian Corneal Graft Register follows over 6000 cases; univariate and multivariate analyses are performed every two years. Amongst the interesting recent findings of the analyses are that a past history of elevated intraocular pressure and early graft suture removal are associated with graft failure, as are the more well-established factors of inflammation, neovascularization, formation of synechiae and recurrence of herpetic eye disease. Donor corneas harvested from relatively elderly donors, however, do not appear to be associated with graft failure. Best-corrected visual acuity achieved post-operatively is very variable, but depends to some extent on the original indication for graft.
角膜移植登记册的价值在于它能够提供有关角膜移植长期结果的新数据，并可能使稀缺供体角膜的分配更加合理。大量的病例和事件能够容纳实践模式中的广泛差异，而不会丧失统计效力。澳大利亚角膜移植登记册跟踪6000多例病例；每两年进行一次单变量和多变量分析。分析中最近一些有趣的发现包括，既往眼压升高史和早期拆除移植缝线与移植失败有关，炎症、新生血管形成、粘连形成和疱疹性眼病复发等已被充分证实的因素也与移植失败有关。然而，从相对年长的供体获取的供体角膜似乎与移植失败无关。术后最佳矫正视力差异很大，但在一定程度上取决于移植的原始适应证。
