Ikeda Y, Matsumata T, Utsunomiya T, Yamagata M, Takenaka K, Sugimachi K
Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
J Surg Oncol. 1995 Feb;58(2):101-3. doi: 10.1002/jso.2930580206.
A rat model of liver metastases generated by intraportal injection of syngeneic tumor cells after two-thirds hepatectomy was used to determine the optimal regional chemotherapeutic modality for early hepatic metastases. WKA rats had viable tumor cells injected directly into the portal vein after two-thirds hepatectomy. Ten rats were used as a control; the remaining groups were given doxorubicin (4/3 mg/kg) injected directly into the hepatic artery at 24 hr, 72 hr, and 7 days (after liver regeneration) postoperatively. The mean survival period in each group was 21.0, 20.0, 20.5, and 20.7 days, respectively, compared with those treated with doxorubicin (4 mg/kg) injection at 24 hr, 72 hr, and 7 days postoperatively, with a mean survival period in each group of 20.0, 21.6, and 25.6 days, respectively. When a comparison was made with regard to the doses of doxorubicin administered, statistically significant differences in survival rates were recognized between the rats that had doxorubicin (4 mg/kg) injection 7 days postoperatively and the others (P < 0.01). Based on these findings, we believe that appropriate adjuvant chemotherapy should be given after the liver regeneration phase.
采用在三分之二肝切除术后经门静脉注射同基因肿瘤细胞建立肝转移大鼠模型，以确定早期肝转移的最佳区域化疗方式。对WKA大鼠在三分之二肝切除术后将活的肿瘤细胞直接注入门静脉。10只大鼠作为对照；其余各组在术后24小时、72小时和7天（肝再生后）经肝动脉直接注射阿霉素（4/3毫克/千克）。与术后24小时、72小时和7天注射阿霉素（4毫克/千克）的组相比，每组的平均生存期分别为21.0天、20.0天、20.5天和20.7天，术后24小时、72小时和7天注射阿霉素（4毫克/千克）的组每组平均生存期分别为20.0天、21.6天和25.6天。在比较所给予的阿霉素剂量时，术后7天注射阿霉素（4毫克/千克）的大鼠与其他大鼠之间的生存率存在统计学显著差异（P<0.01）。基于这些发现，我们认为应在肝再生期后给予适当的辅助化疗。
