Baisac J, Henrich W L
Department of Internal Medicine, Veterans Affairs Medical Center, Dallas, Tex.
Miner Electrolyte Metab. 1994;20(4):187-92.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are important therapeutic agents in the management of rheumatologic disorders and other pain syndromes. Over the counter availability of the drugs has expanded the usage of the drugs. This article reviews the nephrotoxicity of these drugs, with some emphasis on NSAID-related proteinuria. Although reversibility of renal involvement upon drug discontinuance is the rule, progression to end-stage renal disease has occurred. A proposed guideline for monitoring renal impairment in low- and high-risk patients is also presented.
非甾体抗炎药（NSAIDs）是治疗风湿性疾病和其他疼痛综合征的重要药物。这些药物的非处方可得性扩大了其使用范围。本文综述了这些药物的肾毒性，重点讨论了与NSAIDs相关的蛋白尿。虽然停药后肾脏受累通常可逆转，但也有进展至终末期肾病的情况。本文还提出了一项针对低风险和高风险患者监测肾功能损害的建议指南。
