Wang P P, Jernigan T L
Department of Pediatrics, Children's Seashore House, Children's Hospital of Philadelphia, Pennsylvania.
Neurol Clin. 1994 Nov;12(4):789-802.
The contemporary revolution in computerized information processing has enabled the development of methods to quantitate brain morphology in vivo, especially through the analysis of MR imaging. The first brain morphometric studies employed a planimetric approach, usually assessing the cross-sectional areas of midline structures such as the corpus callosum. Subsequently, computer-assisted methods have been developed to quantitate brain volumes, and to segment the white and gray matter and cerebrospinal fluid compartments of the brain. Studies of Tourette, Turner, Down, and Williams syndromes also demonstrate methods that have been used for the morphometry of specific regions within the cerebrum and cerebellum. Although there remain some important issues regarding the interpretation of morphometric results, technological progress will continue to advance the power and availability of brain morphometry. Morphometric data may soon provide useful diagnostic and prognostic information for the practice of pediatric neurogenetics.
当代计算机信息处理革命推动了活体脑形态定量分析方法的发展，特别是通过磁共振成像分析。最初的脑形态测量研究采用了平面测量法，通常评估胼胝体等中线结构的横截面积。随后，已开发出计算机辅助方法来定量脑容量，并对脑白质、灰质和脑脊液腔室进行分割。对图雷特综合征、特纳综合征、唐氏综合征和威廉姆斯综合征的研究也展示了用于大脑和小脑特定区域形态测量的方法。尽管在形态测量结果的解释方面仍存在一些重要问题，但技术进步将继续提升脑形态测量的能力和可用性。形态测量数据可能很快会为儿科神经遗传学实践提供有用的诊断和预后信息。
