Wang H, Bellinger J L, Brierley K, Dawson L E, Goldsmith C L, Hunter A G
Division of Genetics, Children's Hospital of Eastern Ontario, Canada.
Prenat Diagn. 1994 Sep;14(9):868-72. doi: 10.1002/pd.1970140917.
Single copies of tiny chromosome fragments, appearing either as single or as double minutes, were observed in a high frequency in amniotic fluid cultures of five mothers who underwent prenatal testing because of advanced age. In four cases, the minutes had arisen de novo. The minutes were later confirmed in fetal skin following termination of pregnancy in one case; in another, in cord blood following the birth of a normal boy; and in the third, in peripheral blood of a normal 3-year-old girl. In the fourth case, the minutes were not confirmed in cord blood following the birth of a normal boy. A follow-up chromosome study of the baby boy in the fifth case was not possible but the minutes were maternally transmitted.
在五名因高龄接受产前检查的母亲的羊水培养物中，高频观察到微小染色体片段的单拷贝，其呈单分钟或双分钟形式出现。在四个病例中，这些双分钟是新生的。其中一个病例在终止妊娠后，在胎儿皮肤中证实了双分钟的存在；另一个病例在一名正常男婴出生后的脐带血中证实了双分钟的存在；第三个病例在一名正常3岁女孩的外周血中证实了双分钟的存在。在第四个病例中，一名正常男婴出生后，脐带血中未证实双分钟的存在。第五个病例中，对男婴进行后续染色体研究不太可能，但双分钟是由母亲遗传的。
