玉米赤霉烯酮和17β-雌二醇对人脐静脉细胞培养物中前列环素和血栓素生成的影响。

The effect of zearalenone and 17 beta-estradiol on prostacyclin and thromboxane production in cell cultures from human umbilical cord veins.

作者信息

Neuer A, Seeger H, Mück A O, Lippert T H

机构信息

Department of Obstetrics and Gynecology, University of Tübingen, Germany.

出版信息

Prostaglandins Leukot Essent Fatty Acids. 1994 Oct;51(4):241-4. doi: 10.1016/0952-3278(94)90186-4.

DOI:10.1016/0952-3278(94)90186-4

PMID:7846091

Abstract

The effect of zearalenone, a nonsteroidal mycotoxin with estrogenic activity, and of 17 beta-estradiol on prostacyclin and thromboxane production in human endothelial cells was investigated. Zearalenone stimulated prostacyclin production in low concentrations (10(-7) and 10(-8)M) and inhibited it at a higher concentration (10(-5)M). Estradiol alone in the concentration range 10(-5)-10(-8)M had no clear-cut effect on the prostacyclin production. The combination of both substances effected changes in prostacyclin production similar to that from zearalenone alone; with the exception of estradiol at a concentration of 10(-6)M which enhanced the effect of zearalenone. No distinct changes in the thromboxane production from the two substances could be found, either alone or in combination.

摘要

研究了具有雌激素活性的非甾体霉菌毒素玉米赤霉烯酮以及17β-雌二醇对人内皮细胞中前列环素和血栓素生成的影响。玉米赤霉烯酮在低浓度（10^(-7)和10^(-8)M）时刺激前列环素生成，而在较高浓度（10^(-5)M）时抑制其生成。浓度范围在10^(-5)-10^(-8)M的雌二醇单独使用时，对前列环素生成没有明显影响。两种物质的组合对前列环素生成产生的变化类似于单独使用玉米赤霉烯酮时的情况；但10^(-6)M浓度的雌二醇除外，它增强了玉米赤霉烯酮的作用。单独或组合使用这两种物质时，均未发现血栓素生成有明显变化。