Ahles T A, Silberfarb P M, Rundle A C, Holland J C, Kornblith A B, Canellos G P, Green M R, Perry M C
Center for Psycho-Oncology Research, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756.
Psychother Psychosom. 1994;62(3-4):193-9. doi: 10.1159/000288922.
Quality of life was assessed in 57 patients with limited small-cell carcinoma of the lung utilizing psychological scales that measured mood, functional status, and cognitive impairment. These patients received chemotherapy with or without radiotherapy to the primary tumor. All patients received prophylactic cranial radiation. Patients who received the combination of chemotherapy and radiotherapy to both the primary tumor and CNS had an increase in overall survival. However, because of the increased toxicity experienced by these patients, a decrease in quality of life was documented by measures of psychological distress when compared to patients receiving chemotherapy alone. The findings support the importance of utilizing quality of life measures in addition to measures of physical toxicity so that patients can make an informed choice regarding treatment options.
利用测量情绪、功能状态和认知障碍的心理量表，对57例局限性小细胞肺癌患者的生活质量进行了评估。这些患者接受了针对原发肿瘤的化疗，有的还接受了放疗。所有患者均接受了预防性颅脑照射。接受原发肿瘤和中枢神经系统联合化疗与放疗的患者总生存期有所延长。然而，由于这些患者出现了更高的毒性，与仅接受化疗的患者相比，通过心理痛苦测量发现其生活质量有所下降。这些发现支持了除身体毒性测量外，利用生活质量测量的重要性，以便患者能够就治疗方案做出明智的选择。
