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Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy.

作者信息

Charles H C, Lazeyras F, Krishnan K R, Boyko O B, Payne M, Moore D

机构信息

Department of Radiology, Duke University Medical Center, Durham, NC.

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 1994 Nov;18(7):1121-7. doi: 10.1016/0278-5846(94)90115-5.

DOI:10.1016/0278-5846(94)90115-5
PMID:7846284
Abstract
  1. Seven subjects with depression and matched controls were studied using proton spectroscopy to test the hypothesis that choline will be elevated in depression. 2. The proton spectroscopy was repeated after recovery from depression. 3. The study confirmed a state dependent increase in choline in the brain. 4. This change may be used as an in vivo marker of change in depression.
摘要

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