Bloechle M, Halle H, Bollmann R
Universitätsfrauenklinik Charité, Humboldt-Universität, Berlin.
Zentralbl Gynakol. 1994;116(12):697-705.
To evaluate the use of serial measurement of cervical length and width of internal os by means of vaginal ultrasound 144 pregnant women were examined prospectively. We hypothesized, that cervical length and width of the internal os would be significantly different in normal patients and those with preterm labor or cervical incompetence. Predictive validity of suspicious findings indicating the occurrence of preterm labour and cervical incompetence in further course of pregnancy should be assessed. Anamnestic, sonographic and outcome data were analysed. To assess sensitivity, specifity, positive and negative predictive values, different values of cervical length and width of internal os between 20 and 27 weeks were analysed. Significant differences of cervical length and width of internal os in normal and pathologic pregnancies could be documented early in pregnancy course. By further investigation early suspicious findings indicating the developing pathology were found only for the subgroup with cervical incompetence. Sensitivity of vaginal ultrasound examination between 20 and 27 weeks indicating the whole pathologic collective was only 30%, whereas up to 55.5% of pregnancies complicated by cervical incompetence were detected. Specifity (up to 95%) and negative predictive value (90%) were high. The results show that cervical examination by vaginal ultrasound allows early detection of developing cervical incompetence. The high specifity and the high negative predictive value may be useful to exclude cervical incompetence in clinically unclear cases thus helping to avoid unnecessary therapeutical interventions.
为了评估经阴道超声连续测量宫颈长度和内口宽度的应用,我们对144名孕妇进行了前瞻性检查。我们假设,正常孕妇与早产或宫颈机能不全孕妇的宫颈长度和内口宽度会有显著差异。应评估提示妊娠后期早产和宫颈机能不全发生的可疑发现的预测效度。分析了既往史、超声检查及结局数据。为评估敏感性、特异性、阳性和阴性预测值,分析了孕20至27周之间宫颈长度和内口宽度的不同数值。在妊娠早期即可记录到正常妊娠与病理妊娠中宫颈长度和内口宽度的显著差异。通过进一步研究,仅在宫颈机能不全亚组中发现了提示病理发展的早期可疑发现。孕20至27周经阴道超声检查提示整个病理群体的敏感性仅为30%,而宫颈机能不全合并妊娠的检出率高达55.5%。特异性(高达95%)和阴性预测值(90%)较高。结果表明,经阴道超声宫颈检查可早期发现宫颈机能不全的发展情况。高特异性和高阴性预测值可能有助于在临床情况不明时排除宫颈机能不全,从而避免不必要的治疗干预。