Mathis J M, DeNardo A J, Thibault L, Jensen M E, Savory J, Dion J E
Division of Neuroradiology, University of Virginia Health Sciences Center, Charlottesville 22908.
AJNR Am J Neuroradiol. 1994 Oct;15(9):1665-70.
To elucidate, in light of reports of complications associated with intraarterial infusion of papaverine hydrochloride, the known propensity of papaverine hydrochloride to form precipitate in combination with other solutions or pharmaceuticals.
Initially simulating a situation experienced during an intraarterial papaverine infusion for cerebral vasospasm, we mixed various concentrations of papaverine with serum, nonheparinized and heparinized saline, and nonionic contrast material.
Papaverine in concentrations of 0.3% (300 mg/100 mL of normal saline) or greater formed a precipitate when mixed with human serum (blood). The precipitate crystals were 50 to 100 microns in size and could be returned to solution simply by the addition of more serum.
Crystal emboli are a possible transient cause of complications experienced during treatment of vasospasm with its attendant altered flow dynamics.
鉴于有与动脉内输注盐酸罂粟碱相关的并发症报告，阐明盐酸罂粟碱与其他溶液或药物混合时形成沉淀的已知倾向。
最初模拟在动脉内输注罂粟碱治疗脑血管痉挛时遇到的情况，我们将不同浓度的罂粟碱与血清、未肝素化和肝素化盐水以及非离子造影剂混合。
浓度为0.3%（300毫克/100毫升生理盐水）或更高的罂粟碱与人类血清（血液）混合时会形成沉淀。沉淀晶体大小为50至100微米，只需加入更多血清即可重新溶解。
晶体栓子可能是血管痉挛治疗期间出现并发症的一个短暂原因，同时伴有血流动力学改变。
