Pedersen A M, Taylor B K, Payne A M, Abdelrahim M, Francis G L
Department of Pediatrics, Walter Reed Army Medical Center, Washington, DC 20307-5001.
Ann Clin Lab Sci. 1994 Nov-Dec;24(6):548-54.
Placental steroid hormone production appears to be critical in maintaining pregnancy and possibly initiating parturition. Cytokines, produced by activated macrophages and decidua, are present during delivery, but their role in this process is not yet clear. To our knowledge, only one recent study, which used JEG-3 choriocarcinoma cells as an in vitro model, has evaluated the possibility that cytokines might affect placental steroidogenesis. Our current study reports observations on the effect of macrophage conditioned media (MCM, known to contain several cytokines) on the synthesis of progesterone and estradiol by term, normal, human placenta. Macrophage conditioned media significantly decreased progesterone (36 percent) and increased estradiol (76 percent) production by short-term placental organ cultures. These results suggest that macrophage secretory products might significantly alter placental steroidogenesis which could make them important factors in the physiology of parturition.
胎盘类固醇激素的产生似乎对维持妊娠以及可能启动分娩至关重要。由活化巨噬细胞和蜕膜产生的细胞因子在分娩时存在，但其在这一过程中的作用尚不清楚。据我们所知，最近只有一项研究使用JEG-3绒毛膜癌细胞作为体外模型，评估了细胞因子可能影响胎盘类固醇生成的可能性。我们目前的研究报告了关于巨噬细胞条件培养基（MCM，已知含有多种细胞因子）对足月、正常人类胎盘孕酮和雌二醇合成影响的观察结果。巨噬细胞条件培养基通过短期胎盘器官培养显著降低了孕酮产量（36%）并增加了雌二醇产量（76%）。这些结果表明，巨噬细胞分泌产物可能显著改变胎盘类固醇生成，这可能使它们成为分娩生理学中的重要因素。
