Steven F S, Payne P W, Palcic B
Department of Biochemistry and Molecular Biology, School of Bioloical Sciences, University of Manchester, UK.
Anticancer Res. 1994 Sep-Oct;14(5A):2021-4.
A fluorescent probe (rhodamine a-N-agmatine) has been used to locate cells possessing a surface protease in sputum smears. Malignant epithelial cells possess this protease and can be quickly located by this technique. These results have been confirmed by using a second fluorescent probe (9-animo acridine) for this same cell surface protease.