碘普罗胺的临床前测试。第二篇通讯：毒理学评估。

Preclinical testing of iopromide. 2nd communication: toxicological evaluation.

作者信息

Krause W, Schöbel C, Press W R

机构信息

Research Laboratories, Schering Aktiengesellschaft, Berlin, Fed. Rep. of Germany.

出版信息

Arzneimittelforschung. 1994 Nov;44(11):1275-9.

PMID:7848345

Abstract

Toxicological characteristics of the non-ionic monomeric X-ray contrast agent iopromide (Ultravist, CAS 73334-07-3) were evaluated in rats, rabbits, guinea-pigs and dogs. The scope of investigations included acute toxicity studies, systemic tolerance investigations with repeated applications, reproduction toxicity studies, examinations on the genotoxic and contact-sensitizing potential and local tolerance studies. Iopromide could be shown to be well tolerated in all the tests and species.

摘要

对非离子单体X射线造影剂碘普罗胺（优维显，CAS 73334 - 07 - 3）在大鼠、兔、豚鼠和犬身上进行了毒理学特性评估。研究范围包括急性毒性研究、重复给药的全身耐受性研究、生殖毒性研究、遗传毒性和接触致敏潜力检测以及局部耐受性研究。结果表明，在所有测试和物种中，碘普罗胺的耐受性良好。