Bailly C, Colson P, Houssier C, Wang H, Bathini Y, Lown J W
INSERM unité 124 Institut de Recherches sur le Cancer, Lille, France.
J Biomol Struct Dyn. 1994 Aug;12(1):173-81. doi: 10.1080/07391102.1994.10508095.
The binding mode of a series of bis-benzimidazole analogues of Hoechst 33258 to a variety of DNAs and polynucleotides has been investigated by electric linear dichroism. Two groups of compounds were examined: (i) benzoxazole and pyridoimidazole derivatives and (ii) pyridoimidazole analogs substituted with an N-alkoxyalkyl group either directed towards the minor groove or directed away from the minor groove. The ELD data indicate that the mode of binding of these drugs varies significantly with the sequence of the target DNA sequence. The DNA binding properties of these drugs are related to their topoisomerase inhibitory properties.
通过电线性二色性研究了一系列Hoechst 33258的双苯并咪唑类似物与多种DNA和多核苷酸的结合模式。研究了两组化合物：（i）苯并恶唑和吡啶并咪唑衍生物，以及（ii）用N-烷氧基烷基取代的吡啶并咪唑类似物，该取代基要么指向小沟，要么远离小沟。ELD数据表明，这些药物的结合模式随靶DNA序列的不同而有显著差异。这些药物的DNA结合特性与其拓扑异构酶抑制特性有关。
