Papadimitriou J M, Wyche P A
J Pathol. 1976 Aug;119(4):239-54. doi: 10.1002/path.1711190408.
Some biochemical characteristics of peritoneal macrophages, subcutaneous macrophages and subcutaneous cell populations containing multinucleate giant cells were compared. Subcutaneous macrophages possessed higher concentrations of succinate dehydrogenase, acid phosphatase, aryl hydroxylase, free RNase II, lecithin and free fatty acids than peritoneal macrophages, while the latter had higher concentrations of 5' -nucleotidase esterified cholesterol. These differences may be due to environmental variations depending on their anatomical position or more likely to their degree of activation. As significant numbers of multinucleate giant cells appear in the subcutaneous population the concentration aryl hydroxylase, 5' -nucleotidase lactate dehydrogenase, acid phosphatase, free ribonuclease II and esterified cholesterol falls. The concentration of succinate dehydrogenase decreases but then rises while the concentration of glucose-6-phosphate dehydrogenase increases. These highlight the differences between cell populations containing multinucleated giant cells and those composed from their precursor mononuclear phagocytes only.
对腹膜巨噬细胞、皮下巨噬细胞以及含有多核巨细胞的皮下细胞群体的一些生化特性进行了比较。皮下巨噬细胞的琥珀酸脱氢酶、酸性磷酸酶、芳基羟化酶、游离核糖核酸酶II、卵磷脂和游离脂肪酸浓度高于腹膜巨噬细胞，而后者的5'-核苷酸酶和酯化胆固醇浓度更高。这些差异可能是由于其解剖位置导致的环境差异，或者更可能是由于它们的激活程度不同。由于皮下细胞群体中出现大量多核巨细胞，芳基羟化酶、5'-核苷酸酶、乳酸脱氢酶、酸性磷酸酶、游离核糖核酸酶II和酯化胆固醇的浓度下降。琥珀酸脱氢酶的浓度先降低后升高，而葡萄糖-6-磷酸脱氢酶的浓度增加。这些突出了含有多核巨细胞的细胞群体与仅由其前体单核吞噬细胞组成的细胞群体之间的差异。
