通过细胞内稳定性测定反义寡核苷酸对逆转录病毒的抑制作用。
Retroviral inhibition by antisense oligonucleotides determined by intracellular stability.
作者信息
Ropert C, Okruszek A, Couvreur P, Malvy C
机构信息
URA 147 CNRS, U 140 INSERM, Institut Gustave Roussy, Villejuif, France.
出版信息
Antisense Res Dev. 1994 Fall;4(3):207-10. doi: 10.1089/ard.1994.4.207.
PMID:7849491
Abstract
A 15-mer oligodeoxyribonucleotide was found to be efficient toward the Friend retrovirus only when modified or encapsulated in liposomes. The nonmodified oligomer was inefficient. We have measured the intracellular stability of this 15-mer when encapsulated or modified and we have observed a direct relationship between the intracellular stability of the oligonucleotides and their antiretroviral efficiency.
摘要
一个15聚体寡脱氧核糖核苷酸只有在被修饰或包裹于脂质体中时，才对Friend逆转录病毒有效。未修饰的寡聚物则无效。我们已测定了该15聚体在被包裹或修饰时的细胞内稳定性，并且观察到寡核苷酸的细胞内稳定性与其抗逆转录病毒效率之间存在直接关系。
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