Smirnov I V, Feuerstein B G, Pellarin M, Marton L J, Deen D F, Basu H S
Department of Neurological Surgery, School of Medicine, University of California, San Francisco 94143.
Cell Mol Biol (Noisy-le-grand). 1994 Nov;40(7):975-80.
We studied whether pretreatment of U-251 MG human brain tumor cells with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) affected the cytotoxicity of the topoisomerase II inhibitor etoposide. We found that BE-4-4-4-4 protected cells from the cytotoxic effects of etoposide. Possible mechanisms for this protection may be related to enhanced DNA-nuclear matrix association in analog-treated cells.
我们研究了用多胺类似物1,19-双（乙氨基）-5,10,15-三氮杂十九烷（BE-4-4-4-4）预处理U-251 MG人脑肿瘤细胞是否会影响拓扑异构酶II抑制剂依托泊苷的细胞毒性。我们发现BE-4-4-4-4可保护细胞免受依托泊苷的细胞毒性作用。这种保护作用的可能机制可能与类似物处理的细胞中DNA-核基质结合增强有关。
