用多胺类似物1,19 - 双 -（乙氨基）- 5,10,15 - 三氮杂十九烷（BE - 4 - 4 - 4 - 4）进行预处理可抑制依托泊苷对U - 251 MG（NCI）人脑肿瘤细胞的细胞毒性。
Pretreatment with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) inhibits etoposide cytotoxicity in U-251 MG (NCI) human brain tumor cells.
作者信息
Smirnov I V, Feuerstein B G, Pellarin M, Marton L J, Deen D F, Basu H S
机构信息
Department of Neurological Surgery, School of Medicine, University of California, San Francisco 94143.
出版信息
Cell Mol Biol (Noisy-le-grand). 1994 Nov;40(7):975-80.
We studied whether pretreatment of U-251 MG human brain tumor cells with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) affected the cytotoxicity of the topoisomerase II inhibitor etoposide. We found that BE-4-4-4-4 protected cells from the cytotoxic effects of etoposide. Possible mechanisms for this protection may be related to enhanced DNA-nuclear matrix association in analog-treated cells.
我们研究了用多胺类似物1,19-双（乙氨基）-5,10,15-三氮杂十九烷（BE-4-4-4-4）预处理U-251 MG人脑肿瘤细胞是否会影响拓扑异构酶II抑制剂依托泊苷的细胞毒性。我们发现BE-4-4-4-4可保护细胞免受依托泊苷的细胞毒性作用。这种保护作用的可能机制可能与类似物处理的细胞中DNA-核基质结合增强有关。
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