Mason R P, Antich P P
Department of Radiology, UT-Southwestern Medical Center, Dallas 75235-9058.
Artif Cells Blood Substit Immobil Biotechnol. 1994;22(4):1361-7. doi: 10.3109/10731199409138838.
We have used Oxygent (an emulsion of perflubron [PFOB]) to measure pO2 in a Dunning prostatic adenocarcinoma non-invasively using 19F NMR spectroscopy. We have confirmed a linear relationship between the spin-lattice relaxation rate (R1) and pO2 and we have assessed the effect of temperature. R1 of the individual resonances of Oxygent is considerably more sensitive to changes in pO2 than other PFC emulsions, whilst being considerably less sensitive to interference from temperature variation. Oxygent has two well resolved resonances (delta delta approximately 18ppm) and these were both exploited to estimate tumor pO2 = 47 +/- 5 torr.
我们已使用全氟溴辛烷乳剂（Oxygent，一种全氟溴辛烷[PFOB]乳剂），通过19F核磁共振波谱法对邓宁前列腺腺癌中的氧分压（pO2）进行无创测量。我们已证实自旋晶格弛豫率（R1）与pO2之间存在线性关系，并评估了温度的影响。与其他全氟碳化合物乳剂相比，Oxygent各个共振峰的R1对pO2变化的敏感度要高得多，而对温度变化干扰的敏感度则要低得多。Oxygent有两个分辨率良好的共振峰（化学位移差约为18ppm），利用这两个共振峰估计肿瘤的pO2 = 47±5托。
