新型阿朴长春胺酸衍生物VA-045对小鼠的脑保护作用

Cerebral protective effects of VA-045, a novel apovincaminic acid derivative, in mice.

作者信息

Yamada S, Yamaguchi K, Okuyama S

机构信息

Nihon Bioresearch Center Inc., Gifu, Japan.

出版信息

Res Commun Mol Pathol Pharmacol. 1994 Oct;86(1):83-91.

PMID:7850259

Abstract

The cerebral protective effects of VA-045, a novel apovincaminic acid derivative, were investigated in mice under conditions of normobaric hypoxia, histotoxic anoxia by potassium cyanide (KCN), and complete ischemia. VA-045 and thyrotropin releasing hormone (TRH) showed a significant protective effect on normobaric hypoxia. The duration of action of the protective effect of VA-045 was longer than that of TRH. VA-045 but not TRH significantly prolonged the survival time following administration of KCN. VA-045 and TRH showed a positive effect on complete ischemia, and the duration of the protective effect of VA-045 was longer than that of TRH. Beneficial effects of VA-045 for treating cerebral hypoxia, anoxia and ischemia will be discussed.

摘要

在常压缺氧、氰化钾（KCN）所致的组织中毒性缺氧以及完全缺血条件下，对新型阿朴长春胺酸衍生物VA - 045在小鼠体内的脑保护作用进行了研究。VA - 045和促甲状腺激素释放激素（TRH）对常压缺氧显示出显著的保护作用。VA - 045保护作用的持续时间比TRH长。VA - 045能显著延长KCN给药后的存活时间，而TRH则不能。VA - 045和TRH对完全缺血均显示出积极作用，且VA - 045保护作用的持续时间比TRH长。将讨论VA - 045治疗脑缺氧、缺氧和缺血的有益作用。