Lin H J, Perng C L, Lee S D
Department of Medicine, Veterans General Hospital-Taipei, National Yang-Ming University, Taiwan, R.O.C.
Zhonghua Yi Xue Za Zhi (Taipei). 1994 Dec;54(6):389-94.
This study was conducted to evaluate gastric acid and pepsin output in the Chinese patients with liver cirrhosis and duodenal ulcers.
In a period of one year and three months, we prospectively assayed the acid and pepsin responses to sham feeding in 10 healthy males, 20 males with duodenal ulcers, and 11 males with liver cirrhosis.
Although basal and sham feeding stimulated acid outputs were higher in duodenal ulcer patients (2.7 +/- 0.3 and 3.7 +/- 0.3 mEq/h, mean +/- SEM) than in normal subjects (1.6 +/- 0.4 and 2.9 +/- 0.6 mEq/h) and in patients with liver cirrhosis (1.8 +/- 0.4 and 2.1 +/- 0.7 mEq/h), it did not reach statistical significance. Both basal and sham feeding stimulated pepsin outputs were significantly higher in duodenal ulcer patients (11.2 +/- 2.1 and 9.5 +/- 2.2 mg/h) than in normal subjects (2.4 +/- 0.5 and 4.3 +/- 1.2 mg/h) and in patients with liver cirrhosis (3.6 +/- 1.4 and 3.9 +/- 1.2 mg/h) (p < 0.05). The serum gastrin and pepsinogen I concentration in basal and sham feeding conditions demonstrated no statistically significant difference among three groups.
Basal and sham feeding stimulated acid outputs in the Chinese were lower in normal subjects and duodenal ulcer patients as compared with those in the Occidentals. High basal pepsin output may play an important role in the pathogenesis of duodenal ulcers in the Chinese.
本研究旨在评估中国肝硬化合并十二指肠溃疡患者的胃酸和胃蛋白酶分泌情况。
在一年零三个月的时间里，我们前瞻性地测定了10名健康男性、20名十二指肠溃疡男性患者和11名肝硬化男性患者对假饲的酸和胃蛋白酶反应。
尽管十二指肠溃疡患者的基础胃酸分泌量和假饲刺激后的胃酸分泌量（分别为2.7±0.3和3.7±0.3 mEq/h，均值±标准误）高于正常受试者（分别为1.6±0.4和2.9±0.6 mEq/h）和肝硬化患者（分别为1.8±0.4和2.1±0.7 mEq/h），但差异无统计学意义。十二指肠溃疡患者的基础胃蛋白酶分泌量和假饲刺激后的胃蛋白酶分泌量（分别为11.2±2.1和9.5±2.2 mg/h）均显著高于正常受试者（分别为2.4±0.5和4.3±1.2 mg/h）和肝硬化患者（分别为3.6±1.4和3.9±1.2 mg/h）（p<0.05）。三组在基础和假饲条件下的血清胃泌素和胃蛋白酶原I浓度差异无统计学意义。
与西方人相比，中国正常受试者和十二指肠溃疡患者的基础胃酸分泌量和假饲刺激后的胃酸分泌量较低。高基础胃蛋白酶分泌量可能在中国十二指肠溃疡的发病机制中起重要作用。
