Coto-Montes A, Masson-Pévet M, Pévet P, Møller M
Department of Anatomy, University of Oviedo, Spain.
Cell Tissue Res. 1994 Dec;278(3):483-91. doi: 10.1007/BF00331366.
By use of antibodies raised against leu-enkephalin and met-enkephalin immunoreactive, opioidergic bi- and multipolar cells were demonstrated in the pineal gland of the European hamster. Ultrastructural analysis of these opioidergic cells revealed them to be pinealocytes. Processes emerged from the cell bodies and terminated in club-shaped swellings containing many small clear and some larger granular vesicles. Some of the terminals made synapse-like contacts with non-immunoreactive pinealocytes. The presence of the opioidergic pinealocytes strongly indicates that the pineal gland of the European hamster, in addition to its pinealopetal nervous regulation, is regulated by intrapineal peptidergic pinealocytes via a synaptic mechanism. A possible paracrine role of the opioidergic cells must also be considered.
通过使用针对亮氨酸脑啡肽和甲硫氨酸脑啡肽免疫反应性产生的抗体，在欧洲仓鼠的松果体中证实了阿片样物质能的双极和多极细胞。对这些阿片样物质能细胞的超微结构分析显示它们是松果体细胞。细胞体发出突起，终止于含有许多小的清亮囊泡和一些较大颗粒囊泡的棒状肿胀处。一些终末与无免疫反应性的松果体细胞形成突触样接触。阿片样物质能松果体细胞的存在强烈表明，欧洲仓鼠的松果体除了其向心性神经调节外，还通过突触机制受到松果体内肽能松果体细胞的调节。还必须考虑阿片样物质能细胞可能的旁分泌作用。
