Lerch M M, Hernández C A, Adler G
Department of Medicine I, Ulm University Medical School, Germany.
Dig Dis. 1994 Jul-Aug;12(4):242-7. doi: 10.1159/000171458.
The observation that necrotizing pancreatitis and gallstones can be associated is more than 300 years old [1]. Since the beginning of our century, numerous investigations have addressed the question as to how gallstones cause pancreatitis. Despite this effort and many excellent clinical and experimental studies, few pathophysiological issues in gastroenterology have remained so controversial and even fewer have found advocates with such incompatible views and uncompromising convictions. We will review the past and present theories regarding the pathophysiology of gallstone-induced pancreatitis and outline the therapeutic consequences implied by these concepts.
坏死性胰腺炎与胆结石可能相关的这一观察已有300多年的历史[1]。自本世纪初以来，众多研究都围绕胆结石如何引发胰腺炎这一问题展开。尽管付出了这些努力以及进行了许多出色的临床和实验研究，但胃肠病学中很少有病理生理学问题如此具有争议性，并且几乎没有问题能找到持有如此不相容观点和坚定信念的支持者。我们将回顾过去和现在关于胆结石性胰腺炎病理生理学的理论，并概述这些概念所蕴含的治疗意义。
