Aoki K, Okazaki N, Okada S, Nose H, Yoshimori M, Akine Y, Egawa S, Sakamoto M, Hirohashi S
Department of Internal Medicine, National Cancer Center Hospital, Tokyo, Japan.
Hepatogastroenterology. 1994 Oct;41(5):427-31.
The clinical value of radiotherapy for hepatocellular carcinoma (total tumor dose: 50-70 Gy) was evaluated in seven autopsied patients with nine tumors. A partial response as defined by the WHO criteria for chemotherapy was observed in three tumors (33%). Progressive and marked shrinkage of the noncancerous liver tissue within the irradiated field was also observed in all cases. Histological examination revealed viable cancer cells in all cases. These results indicate that local radiotherapy applying 50-70 Gy achieved some clinical benefit, but was not capable of curing hepatocellular carcinoma.
对7例尸检患者的9个肿瘤评估了放射治疗（总肿瘤剂量：50 - 70 Gy）对肝细胞癌的临床价值。根据WHO化疗标准定义，在3个肿瘤（33%）中观察到部分缓解。在所有病例中还观察到照射野内非癌性肝组织的进展性和明显萎缩。组织学检查显示所有病例中均存在存活的癌细胞。这些结果表明，应用50 - 70 Gy的局部放射治疗取得了一定的临床益处，但不能治愈肝细胞癌。
