Saxena R K, Sahay K B, Guha S K
Centre for Atmospheric Sciences, Indian Institute of Technology, New Delhi.
Indian J Med Res. 1994 Oct;100:201-7.
Variations in proteoglycans and water content of the knee joint cartilage were found to occur when the joint was subjected to articulating motion under moderate and high loadings. It was found that at a moderate load of 150 kg there were an increase in the percentage of proteoglycans but the percentage decreased when the joint was articulated at a high loading of 300 kg. It has also been observed that the ratio of water content and the proteoglycans decreased at moderate load, whereas the ratio increased at high load. The observed changes in proteoglycans and water content in extracellular matrix with moderate and high loadings suggested that articular cartilage properties respond to mechanical stresses.
当膝关节在中等和高负荷下进行关节运动时，发现膝关节软骨中的蛋白聚糖和水分含量会发生变化。研究发现，在150千克的中等负荷下，蛋白聚糖的百分比会增加，但当关节在300千克的高负荷下进行关节运动时，该百分比会下降。还观察到，在中等负荷下，水分含量与蛋白聚糖的比率会下降，而在高负荷下该比率会上升。在中等和高负荷下细胞外基质中蛋白聚糖和水分含量的观察变化表明，关节软骨特性会对机械应力作出反应。
