Cairnduff F, Roberts D J, Dixon B, Brown S B
Research School of Medicine, University of Leeds, UK.
Int J Radiat Biol. 1995 Jan;67(1):93-9. doi: 10.1080/09553009514550121.
The effects of 5-aminolaevulinic acid (ALA)-based photodynamic therapy (PDT) on the growth of an intradermal rat fibrosarcoma have been determined following topical, intravenous, or intratumour application of ALA. The pattern of tumour growth was identical following each type of therapy and we conclude that the efficacy of ALA-PDT is independent of the route of drug administration, at least in this tumour system. We have also compared the efficacy of interstitial ALA-based PDT with similar therapy using a conventional photosensitizer, polyhaematoporphyrin (PHP). ALA-PDT was less effective than PHP-based therapy at inhibiting the growth of a subcutaneous rat fibrosarcoma at light doses over 300 J. It is suggested that protoporphyrin IX photo-bleaching may limit the effectiveness of treatment, whilst the more bleach-resistant PHP may continue to be effective at higher light doses.
在对大鼠皮内纤维肉瘤进行局部、静脉或瘤内应用5-氨基乙酰丙酸（ALA）后，已确定基于ALA的光动力疗法（PDT）对该肿瘤生长的影响。每种治疗方式后肿瘤生长模式相同，我们得出结论，至少在这个肿瘤系统中，ALA-PDT的疗效与药物给药途径无关。我们还比较了基于间质ALA的PDT与使用传统光敏剂聚血卟啉（PHP）的类似疗法的疗效。在光剂量超过300 J时，ALA-PDT在抑制皮下大鼠纤维肉瘤生长方面不如基于PHP的疗法有效。有人认为，原卟啉IX的光漂白可能会限制治疗效果，而更耐漂白的PHP在更高光剂量下可能仍然有效。
