戊巴比妥和乙醚麻醉对大鼠下丘脑促黄体激素释放激素的影响。

The effects of pentobarbital and ether anesthesia on hypothalamic LH-RH in the rat.

作者信息

Morris M, Knigge K M

出版信息

Neuroendocrinology. 1976;20(3):193-200. doi: 10.1159/000122483.

Abstract

The effects of ether and pentobarbital anesthesia on hypothalamic and cerebrospinal fluid (CSF) LH-RH content were studied in male rats. Ether elevated hypothalamic LH-RH 30 min after a 3-min exposure; pentobarbital (30 mg/kgital (30mg/kg) caused no change. The ether-induced increase in LH-RH content was not affected by pretreatment with pentobarbital; however, the increase was abolished in animals subjected to hypothalamic deafferentation. Changes in CSF LH-RH generally paralleled the hypothalamic changes; ether, for example, elicited a significant rise. These results demonstrate the complex hypothalamo-pituitary-CSF interactions which occur in response to general anesthetics.

摘要

研究了乙醚和戊巴比妥麻醉对雄性大鼠下丘脑和脑脊液（CSF）中促性腺激素释放激素（LH-RH）含量的影响。暴露于乙醚3分钟后30分钟，下丘脑LH-RH升高；戊巴比妥（30mg/kg）未引起变化。戊巴比妥预处理不影响乙醚诱导的LH-RH含量增加；然而，在下丘脑去传入神经的动物中，这种增加被消除。脑脊液中LH-RH的变化通常与下丘脑的变化平行；例如，乙醚引起显著升高。这些结果证明了全身麻醉时发生的下丘脑-垂体-脑脊液之间复杂的相互作用。