Litvan I, Sirigu A, Toothman J, Grafman J
Neuroepidemiology Branch, NINDS, National Institutes of Health, Bethesda, MD 20892.
Neurology. 1995 Feb;45(2):387-9. doi: 10.1212/wnl.45.2.387.
Autobiographic memory is reported to be impaired in patients with Alzheimer's disease (AD). To determine if cholinergic blockade fully reproduces the amnestic disorder found in dementia, we evaluated aspects of autobiographic and episodic memory in six healthy elderly controls after both scopolamine and placebo administration compared with untreated age- and education-matched patients with AD. The performance of patients with AD was significantly worse than that of controls after both treatment conditions. Scopolamine impaired episodic but not autobiographic memory. Thus, even though the cholinergic system is severely affected in patients with AD, muscarinic blockade alone does not seem to be a good model of this disorder.
据报道，阿尔茨海默病（AD）患者的自传体记忆受损。为了确定胆碱能阻断是否能完全重现痴呆症中发现的遗忘症，我们在六名健康老年对照者注射东莨菪碱和安慰剂后，评估了他们的自传体记忆和情景记忆方面，并与未接受治疗、年龄和教育程度匹配的AD患者进行比较。在两种治疗条件下，AD患者的表现均显著差于对照组。东莨菪碱损害了情景记忆，但未损害自传体记忆。因此，尽管AD患者的胆碱能系统受到严重影响，但仅毒蕈碱阻断似乎并不是这种疾病的良好模型。
