Kruszewski J, Zaraś E
Kliniki Chorób Zakaźnych Instytutu Medycyny Wewnetrznej Centralnego Szpitala Klinicznego WAM, Warszawie.
Pol Tyg Lek. 1994;49(14-15):337-40.
An effect of cetirizine--one of antihistaminic agents--on the rate of adverse reactions to the specific desensitization has been evaluated in patients with atopic respiratory diseases. The study included 270 patients desensitized in 1988-1993 for the atopic diseases due to hypersensitivity to grass pollens and Dermatophagoides pteronyssinus. Standard Alvac-P. Pollinex, and Alvac-S HDM vaccines have been used. Occurrence and severity of the adverse reactions noted during 3,368 injections of vaccines have been analysed. Frequency and adverse reactions severity have been compared for two periods--1988-1990 when patients have not been given antihistaminic agent, and 1991-1993--when ceterizine has been administered during the whole period of desensitization. It has been found that simultaneous cetirizine administration decreases frequency and severity of adverse reaction to the used vaccines. Such a procedure may be recommended to patients with advance hypersensitivity given vaccines in out-patient clinics.
在患有特应性呼吸道疾病的患者中，已评估了抗组胺药之一西替利嗪对特异性脱敏不良反应发生率的影响。该研究纳入了1988年至1993年因对草花粉和屋尘螨过敏而针对特应性疾病进行脱敏的270例患者。使用了标准的Alvac - P、Pollinex和Alvac - S HDM疫苗。分析了在3368次疫苗注射过程中记录的不良反应的发生情况和严重程度。比较了两个时期的不良反应频率和严重程度——1988年至1990年患者未服用抗组胺药时，以及1991年至1993年——在整个脱敏期间服用西替利嗪时。已发现同时服用西替利嗪可降低所用疫苗不良反应的频率和严重程度。对于在门诊接受疫苗接种的预先存在超敏反应的患者，可推荐采用这种方法。
