Gholson C F, McDonald J, McMillan R
Department of Medicine, Louisiana State University Medical Center, Shreveport 71130-3932.
Postgrad Med. 1995 Feb;97(2):101-4, 107-9, 113-4.
Orthotopic liver transplantation is an established form of therapy for selected patients who have chronic parenchymal liver disease with cirrhosis, a chronic cholestatic syndrome, fulminant hepatic failure, or unresectable hepatic malignant disease. In most centers with experienced staff, 5-year survival rates exceed 70%. For a good outcome, it is essential that the patient be referred to a transplant center early, before overt clinical deterioration occurs. Following transplantation, lifelong immunosuppression is required to prevent allograft rejection, and extensive follow-up is necessary for early reversal of complications. The primary care physician plays a critical role in identifying organ donors.
原位肝移植是一种针对特定患者的既定治疗方式，这些患者患有伴有肝硬化的慢性实质性肝病、慢性胆汁淤积综合征、暴发性肝衰竭或无法切除的肝脏恶性疾病。在大多数拥有经验丰富工作人员的中心，5年生存率超过70%。为了取得良好的治疗效果，至关重要的是在患者出现明显临床恶化之前尽早将其转诊至移植中心。移植后，需要终身进行免疫抑制以防止移植物排斥反应，并且需要进行广泛的随访以便早期逆转并发症。初级保健医生在识别器官捐献者方面发挥着关键作用。
