dos Reis-Filho J B, Matas S L, Fischman O, Morales B C, Juliano Y
Setor de Líquido Cefalorraquiano-Escola Paulista de Medicina, São Paulo/SP, Brasil.
Rev Inst Med Trop Sao Paulo. 1994 May-Jun;36(3):225-30.
Neurocryptococcosis was a rare nervous system infection. With the rising number of patients with AIDS it became a very frequent disease. This infection is supposed to infect patients with some kind of immunodeficiency and the CSF alterations often simulate tuberculous meningitis. The purpose of this research was to compare the CSF changes in AIDS and non-AIDS patients with meningoencephalitis caused by Cr. neoformans. There were analysed 41 CSF samples from non-AIDS patients with neurocryptococcosis and 23 CSF samples from AIDS patients with neurocryptococcosis. The results of this research allowed to conclude that the inflammatory changes in the CSF from AIDS patients showed a lower intensity compared to those non-AIDS patients. These results showed as well, that the CSF samples from non-AIDS patients always revealed some changes besides the yeast cells. In some samples of AIDS patients, however the unique change was the presence of the yeast. It was demonstrated also, that the presence of Cr. neoformans in CSF, not accompanied by any other change, may suggest that is a patient with AIDS. In non-AIDS patients CSF alterations often simulates tuberculous meningitis. However these alterations were rare in AIDS patients. The yeast cells were more numerous in CSF samples from AIDS patients than in those from non-AIDS patients.
新型隐球菌性脑膜炎是一种罕见的神经系统感染。随着艾滋病患者数量的增加，它已成为一种非常常见的疾病。这种感染被认为会感染某种免疫缺陷的患者，其脑脊液改变常类似结核性脑膜炎。本研究的目的是比较艾滋病患者和非艾滋病患者由新型隐球菌引起的脑膜脑炎的脑脊液变化。分析了41例非艾滋病新型隐球菌性脑膜炎患者的脑脊液样本和23例艾滋病新型隐球菌性脑膜炎患者的脑脊液样本。本研究结果表明，与非艾滋病患者相比，艾滋病患者脑脊液中的炎症变化强度较低。这些结果还表明，非艾滋病患者的脑脊液样本除了酵母细胞外总是显示出一些变化。然而，在一些艾滋病患者的样本中，唯一的变化是酵母的存在。研究还表明，脑脊液中存在新型隐球菌而无任何其他变化，可能提示该患者患有艾滋病。在非艾滋病患者中，脑脊液改变常类似结核性脑膜炎。然而，这些改变在艾滋病患者中很少见。艾滋病患者脑脊液样本中的酵母细胞比非艾滋病患者的更多。
